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Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3)

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PC1-like 3 protein; Polycystin-1L3

Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3)
CCC K083
HGNC 21716
MGI 2664670
PubMed 22420714
UniProt Q7Z443
The deduced 1,732-amino acid PKD1L3 protein contains an N-terminal C-type lectin domain, followed by a central GPCR proteolytic site and PLAT domain, a pair of PKD domains, and a C-terminal putative channel pore region. It also has 11 transmembrane domains.
PKD1L3 does not possess the receptor egg jelly domain found in PKD1L2. Confocal microscopy and coimmunoprecipitation analysis revealed coexpression of Pkd1l3 and Pkd2l1, but not Trpm5, in the apical ends of taste cells in circumvallate and foliate papillae. Coexpression of Pkd1l3 and Pkd2l1 was necessary for inducing changes in intracellular calcium concentration in response to acid solutions, suggesting that PKD1L3/PKD2L1 heteromers function as sour taste receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polycystic Kidney Disease 1 Like Protein 3 (PKD1L3) ELISA Kit Customized Service Offer
  1. "Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes."Genomics 81:596-608(2003) [PubMed] [Europe PMC] [Abstract]
  2. ErratumGenomics 82:498-500(2003)
  3. "Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1."EMBO Rep. 9:690-697(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor."Biochem. Biophys. Res. Commun. 385:346-350(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue."PLoS ONE 4:E7347-E7347(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae."FASEB J. 24:4058-4067(2010) [PubMed] [Europe PMC] [Abstract]
  7. "The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs."FEBS J. 279:1857-1870(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex."Nat. Commun. 3:1252-1252(2012) [PubMed] [Europe PMC] [Abstract]