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Vacuolar Protein Sorting 4B (VPS4B)

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MIG1; SKD1; VPS42; SKD1B; Suppressor Of K+ Transport Defect 1; Cell migration-inducing gene 1 protein

Vacuolar Protein Sorting 4B (VPS4B)
CCC K095
HGNC 10895
MGI 1100499
PubMed 17553870
RGD 1305969
UniProt O75351
Wiki VPS4B
VPS4B is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins.
Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 4B (VPS4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 4B (VPS4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 4B (VPS4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 4B (VPS4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 4B (VPS4B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 4B (VPS4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 4B (VPS4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 4B (VPS4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 4B (VPS4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 4B (VPS4B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 4B (VPS4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 4B (VPS4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 4B (VPS4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 4B (VPS4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 4B (VPS4B) ELISA Kit Customized Service Offer
  1. "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking."J. Mol. Biol. 312:469-480(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative sequence and expression analyses of four mammalian VPS4 genes."Gene 305:47-59(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins."J. Cell Sci. 114:2395-2404(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding."Dev. Cell 15:62-73(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly."Mol. Biol. Cell 19:2661-2672(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Helical structures of ESCRT-III are disassembled by VPS4."Science 321:1354-1357(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Biochemical analyses of human IST1 and its function in cytokinesis."Mol. Biol. Cell 20:1360-1373(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structural characterization of the MIT domain from human Vps4b."Biochem. Biophys. Res. Commun. 334:460-465(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Structural and mechanistic studies of VPS4 proteins."EMBO J. 24:3658-3669(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Solution structure of MIT domain from human SKD1."Submitted (NOV-2005) to the PDB data bank
  25. "ESCRT-III recognition by VPS4 ATPases."Nature 449:740-744(2007) [PubMed] [Europe PMC] [Abstract]