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Carbohydrate Sulfotransferase 4 (CHST4)

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LSST; GST3; Gn6st-2; L-selectin ligand sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase 2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3

Carbohydrate Sulfotransferase 4 (CHST4)
CCC K100
HGNC 1972
MGI 1349479
PubMed 1433500
RGD 1310798
UniProt Q8NCG5
Wiki CHST4
CHST4, a golgi resident carbohydrate sulfotransferase, has been described as an HEV restricted sulfotransferase in part responsible for the sulfation step required for L selectin: PNAd interaction. The MECA79 antibody which recognizes sulfated PNAd provides a useful tool for monitoring sulfotransferase activity. The presence of both CHST4 and the MECA79 sulfated epitope have been described in HEV as well as lymphoid aggregates and tertiary lymphoid tissues at the sites of chronic inflammation.
Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues. Expressed in colonic mucinous adenocarcinoma. Upon cytokine activation, it is expressed at low level.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 4 (CHST4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 4 (CHST4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 4 (CHST4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 4 (CHST4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 4 (CHST4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 4 (CHST4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 4 (CHST4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 4 (CHST4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 4 (CHST4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 4 (CHST4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbohydrate Sulfotransferase 4 (CHST4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbohydrate Sulfotransferase 4 (CHST4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbohydrate Sulfotransferase 4 (CHST4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbohydrate Sulfotransferase 4 (CHST4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbohydrate Sulfotransferase 4 (CHST4) ELISA Kit Customized Service Offer
  1. "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin."J. Cell Biol. 145:899-910(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase."Cell 105:957-969(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family."Glycobiology 11:75-87(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin."J. Leukoc. Biol. 69:565-574(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma."Glycobiology 12:379-388(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression."J. Biol. Chem. 277:3979-3984(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis."J. Biol. Chem. 278:40282-40295(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity."J. Biol. Chem. 279:40035-40043(2004) [PubMed] [Europe PMC] [Abstract]