Nitrogen Permease Regulator Like Protein 3 (NPRL3)

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CGTHBA; RMD11; NPR3; MARE; HS-40; Conserved Gene Telomeric To Alpha Globin Cluster; Alpha-globin regulatory element-containing gene protein

Nitrogen Permease Regulator Like Protein 3 (NPRL3)
NPRL3 spans about 55 kb or approximately half of the DNA proximal to the telomere and subtelomeric region. The gene consists of 15 exons and the cDNA encodes a predicted 544- or 569-amino acid protein, depending on the alternative splicing of exon 5. Two mRNAs of 3.2 and 2.5 kb were detected in a variety of cell lines .
Curiously, a previously identified erythroid-specific regulatory element occurs within intron 5. This regulatory sequence does not influence expression of the gene, which has a GC-rich promoter (unlike the TATA-type promoters of the alpha globin loci). The authors showed that the sequence of the gene and its location adjacent to alpha globin loci has been conserved for at least 270 million years.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

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Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
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n/a Polyclonal Antibody to Nitrogen Permease Regulator Like Protein 3 (NPRL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nitrogen Permease Regulator Like Protein 3 (NPRL3) CLIA Kit Customized Service Offer
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  1. "Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element."Genomics 29:679-689(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter."Science 312:1215-1217(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex."PLoS Genet. 5:E1000515-E1000515(2009) [PubMed] [Europe PMC] [Abstract]
  5. "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1."Science 340:1100-1106(2013) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]