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Meiotic Recombination 11 Homolog A (MRE11A)

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ATLD; HNGS1; MRE11; MRE11B; AT-Like Disease

Meiotic Recombination 11 Homolog A (MRE11A)
CCC K113
HGNC 7230
MGI 1100512
PubMed 24623370
RGD 69263
UniProt P49959
Wiki MRE11A
MRE11A encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK113Hu01 Recombinant Meiotic Recombination 11 Homolog A (MRE11A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK113Hu01 Polyclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Meiotic Recombination 11 Homolog A (MRE11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meiotic Recombination 11 Homolog A (MRE11A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Meiotic Recombination 11 Homolog A (MRE11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Meiotic Recombination 11 Homolog A (MRE11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meiotic Recombination 11 Homolog A (MRE11A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Meiotic Recombination 11 Homolog A (MRE11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Meiotic Recombination 11 Homolog A (MRE11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Meiotic Recombination 11 Homolog A (MRE11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Meiotic Recombination 11 Homolog A (MRE11A) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of the human MRE11 homologue."Genomics 29:80-86(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks."Mol. Cell 1:969-979(1998) [PubMed] [Europe PMC] [Abstract]
  3. "hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay."Hum. Mol. Genet. 10:1155-1162(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response."Mol. Cell. Biol. 24:9207-9220(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage."Cancer Sci. 96:134-141(2005) [PubMed] [Europe PMC] [Abstract]
  9. "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response."Mol. Cell 18:577-587(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links."Oncogene 27:5045-5056(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex."J. Virol. 84:12504-12514(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling." Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder."Cell 99:577-587(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Alterations of the double-strand break repair gene MRE11 in cancer."Cancer Res. 61:23-26(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility."J. Med. Genet. 40:E131-E131(2003) [PubMed] [Europe PMC] [Abstract]
  26. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]