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NLR Family, Pyrin Domain Containing Protein 1 (NLRP1)

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NAC; CARD7; CLR17.1; DEFCAP; DEFCAP-L/S; NALP1; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein

NLR Family, Pyrin Domain Containing Protein 1 (NLRP1)
CCC K117
HGNC 14374
MGI 2684861
PubMed 23382179
RGD 1310963
UniProt Q9C000
Wiki NLRP1
NLRP1 encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.Widely expressed. Isoforms 1 and 2 are expressed in peripheral blood leukocytes and chronic myelogenous leukemia cell line K-562, followed by thymus, spleen and heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK117Hu01 Recombinant NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK117Hu01 Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Pyrin Domain Containing Protein 1 (NLRP1) ELISA Kit Customized Service Offer
  1. "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins."Cell Death Differ. 7:1273-1274(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation."Curr. Biol. 11:R118-R120(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins."J. Biol. Chem. 276:9230-9238(2001) [PubMed] [Europe PMC] [Abstract]
  4. "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis."J. Biol. Chem. 276:9239-9245(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta."Mol. Cell 10:417-426(2002) [PubMed] [Europe PMC] [Abstract]
  11. "NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells."Biochem. J. 384:281-286(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Expression of NALP1 in cerebellar granule neurons stimulates apoptosis."Cell. Signal. 16:1013-1021(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Inflammasome components NALP 1 and 3 Show distinct but separate Expression profiles in human tissues suggesting a site-specific role in the inflammatory response."J. Histochem. Cytochem. 55:443-452(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation."Mol. Cell 25:713-724(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Novel role of PKR in inflammasome activation and HMGB1 release."Nature 488:670-674(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis." J. Med. Genet. 50:246-254(2013) [PubMed] [Europe PMC] [Abstract]
  18. "NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain."Structure 11:1199-1205(2003) [PubMed] [Europe PMC] [Abstract]
  19. "NALP1 in vitiligo-associated multiple autoimmune disease."N. Engl. J. Med. 356:1216-1225(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Northeast structural genomics consortium target HR3486E."Submitted (OCT-2009) to the PDB data bank