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Pre-mRNA Processing Factor 4 (PRPF4)

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Prp4p; HPRP4; HPRP4P; PRP4; WD splicing factor Prp4; PRP4/STK/WD Splicing Factor; U4/U6 Small Nuclear Ribonucleoprotein Prp4

Pre-mRNA Processing Factor 4 (PRPF4)
CCC K118
HGNC 17349
MGI 1917302
PubMed 24419317
RGD 1311303
UniProt O43172
Wiki PRPF4
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.
The deduced 521-amino acid protein has a calculated molecular mass of about 58.5 kD. By Western blot analysis, PRPF4 showed an apparent molecular mass of about 55 kD. PRPF4 contains 7 WD repeats that cover the entire C-terminal portion of the protein. These repeats are predicted to form a 7-fold beta propeller, like those found in the beta subunits of heterotrimeric G proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 4 (PRPF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 4 (PRPF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 4 (PRPF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 4 (PRPF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 4 (PRPF4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 4 (PRPF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 4 (PRPF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 4 (PRPF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 4 (PRPF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 4 (PRPF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 4 (PRPF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 4 (PRPF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 4 (PRPF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 4 (PRPF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 4 (PRPF4) ELISA Kit Customized Service Offer
  1. "The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p."RNA 3:926-941(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs."RNA 3:1374-1387(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome."Hum. Mol. Genet. 6:2117-2126(1997) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor."Genes Dev. 11:139-151(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "PRPF4 mutations cause autosomal dominant retinitis pigmentosa."Hum. Mol. Genet. 23:2926-2939(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide."J. Mol. Biol. 331:45-56(2003) [PubMed] [Europe PMC] [Abstract]