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Pre-mRNA Processing Factor 3 (PRPF3)

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PRP3; HPRP3; RP18; Retinitis Pigmentosa 18; U4/U6 snRNP 90 kDa protein; U4/U6 small nuclear ribonucleoprotein Prp3

Pre-mRNA Processing Factor 3 (PRPF3)
CCC K119
HGNC 17348
MGI 1918017
PubMed 12714658
RGD 1310555
UniProt O43395
Wiki PRPF3
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is 1 of several proteins that associate with U4 and U6 snRNPs.
PRP3 shares significant homology with yeast and nematode Prp3, with the similarity limited to their C-terminal halves.Overall, PRP3 has a large percentage of basic residues (18% arginine and lysine). PRP3 also contains 3 sequences that are homologous to one another and that share a central ELK motif. It also has a region with some similarity to a double-stranded RNA-binding motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 3 (PRPF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 3 (PRPF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 3 (PRPF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 3 (PRPF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 3 (PRPF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 3 (PRPF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 3 (PRPF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 3 (PRPF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 3 (PRPF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 3 (PRPF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 3 (PRPF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 3 (PRPF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 3 (PRPF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 3 (PRPF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 3 (PRPF3) ELISA Kit Customized Service Offer
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  2. "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs."RNA 3:1374-1387(1997) [PubMed] [Europe PMC] [Abstract]
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  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
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  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome."Genes Dev. 24:1434-1447(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein PRP3(HPRP3)."Submitted (NOV-2005) to the PDB data bank
  19. "Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa."Hum. Mol. Genet. 11:87-92(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa."Invest. Ophthalmol. Vis. Sci. 44:2171-2177(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Mutation in the splicing factor Hprp3p linked to retinitis pigmentosa impairs interactions within the U4/U6 snRNP complex."Hum. Mol. Genet. 17:225-239(2008) [PubMed] [Europe PMC] [Abstract]