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Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP)

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DTL; CDT2; DCAF2; L2DTL; CDW1; L2DTL; RAMP; Denticleless Homolog; DDB1 And CUL4 Associated Factor 2; Lethal(2) denticleless protein

Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP)
CCC K144
HGNC 30288
MGI 1924093
PubMed 22434110
RGD 1310439
UniProt Q9NZJ0
RAMP is rich in serines, threonines, and basic residues. It has 2 WD repeats, a putative leucine zipper, a nuclear localization signal, a putative SH3-binding motif, 5 potential glycosylation sites, and several potential phosphorylation sites. In vitro translation resulted in an 85-kD RAMP protein.
RAMP mRNA and protein levels decreased in NT2 cells following RA treatment. RAMP translocated from the interphase nucleus to the metaphase cytoplasm during mitosis. During late-stage cytokinesis, RAMP concentrated at the midzone of dividing daughter cells. RAMP mRNA levels showed a positive correlation with the rate of cell proliferation, and overexpression of RAMP in NT2 cells induced a transient increase in proliferation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoic Acid Regulated Nuclear Matrix Associated Protein (RAMP) ELISA Kit Customized Service Offer
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  2. "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage."Cell Cycle 5:1675-1680(2006) [PubMed] [Europe PMC] [Abstract]
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  6. "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma."Cell Cycle 5:2676-2687(2006) [PubMed] [Europe PMC] [Abstract]
  7. "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint."Genes Dev. 20:3117-3129(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
  9. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery."Nature 443:590-593(2006) [PubMed] [Europe PMC] [Abstract]
  11. "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex."Genes Dev. 22:2496-2506(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing."Genes Dev. 22:2507-2519(2008) [PubMed] [Europe PMC] [Abstract]
  13. "CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation."J. Biol. Chem. 283:29045-29052(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells."J. Biol. Chem. 284:15061-15070(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis."Mol. Cell 37:143-149(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of TGF-beta signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2."Cell Cycle 12:2175-2182(2013) [PubMed] [Europe PMC] [Abstract]
  25. "CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration."Mol. Cell 49:1147-1158(2013) [PubMed] [Europe PMC] [Abstract]
  26. "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase."Mol. Cell 49:1159-1166(2013) [PubMed] [Europe PMC] [Abstract]