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Fanconi Anemia Complementation Group M (FANCM)

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FAAP250; ATP-dependent RNA helicase FANCM; Fanconi anemia-associated polypeptide of 250 kDa; Protein Hef ortholog

Fanconi Anemia Complementation Group M (FANCM)
CCC K190
HGNC 23168
MGI 2442306
PubMed 10997877
UniProt Q8IYD8
Wiki FANCM
FANCM displays ATPase activity and promotes dissociation of DNA triplexes. It is believed that FANCM in conjunction with other Fanconi anemia-associated proteins repair DNA at stalled replication forks.
Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group M (FANCM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group M (FANCM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group M (FANCM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group M (FANCM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group M (FANCM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group M (FANCM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group M (FANCM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group M (FANCM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group M (FANCM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group M (FANCM) ELISA Kit Customized Service Offer
  1. "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M."Nat. Genet. 37:958-963(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway."Nat. Struct. Mol. Biol. 12:763-771(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM."Mol. Cell 25:331-343(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability." Mol. Cell 37:865-878(2010)
  9. "MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM."Mol. Cell 37:879-886(2010)