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Fanconi Anemia Complementation Group I (FANCI)

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FACI

Fanconi Anemia Complementation Group I (FANCI)
CCC K192
HGNC 25568
MGI 2384790
PubMed 11347906
UniProt Q9NVI1
Wiki FANCI
FANCI, a monoubiquitinated paralog of FANCD2, belongs to the Fanconi anemia (FA) DNA interstrand cross-link repair pathway and is required for resistance to mitomycin C.
The predicted protein contains 802 amino acids. RT-PCR ELISA detected moderate expression in testis and fetal liver and low expression in lung, liver, spleen, ovary, and adult and fetal brain. Expression was very low or undetectable in all other tissues tested. Expression was low in all specific brain regions examined, with slightly higher expression in cerebellum.The predicted FANCI protein contains 1,328 amino acids and has a calculated molecular mass of 146 kD. It has 3 nuclear localization signals and 3 ATM/ATR phosphorylation motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group I (FANCI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group I (FANCI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group I (FANCI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group I (FANCI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group I (FANCI) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group I (FANCI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group I (FANCI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group I (FANCI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group I (FANCI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group I (FANCI) ELISA Kit Customized Service Offer
  1. "Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair."Cell 129:289-301(2007) [PubMed] [Europe PMC] [Abstract]
  2. "FANCI is a second monoubiquitinated member of the Fanconi anemia pathway."Nat. Struct. Mol. Biol. 14:564-567(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]