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Fanconi Anemia Complementation Group E (FANCE)

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FACE; FAE

Fanconi Anemia Complementation Group E (FANCE)
CCC K193
HGNC 3586
MGI 1920025
PubMed 7662964
RGD 1561045
UniProt Q9HB96
Wiki FANCE
FANCE has 10 exons and encodes a novel 536-amino acid protein with 2 potential nuclear localization signals. Three separate mutations were identified, 2 in patients in Turkey and 1 in a patient in Bangladesh.
FANCE protein is part of this nuclear complex, binding both FANCC and FANCD2. Indeed, FANCE is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Disease-associated FANCC mutants do not bind to FANCE, cannot accumulate in the nucleus and are unable to prevent chromosome breakage.The FACE group is defined as being different from groups A, B, C, and D and may itself be heterogeneous.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group E (FANCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group E (FANCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group E (FANCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group E (FANCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group E (FANCE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group E (FANCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group E (FANCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group E (FANCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group E (FANCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group E (FANCE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group E (FANCE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group E (FANCE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group E (FANCE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group E (FANCE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group E (FANCE) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "FANCE: the link between Fanconi anaemia complex assembly and activity."EMBO J. 21:3414-3423(2002) [PubMed] [Europe PMC] [Abstract]
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  9. "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M."Nat. Genet. 37:958-963(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway."Mol. Cell. Biol. 27:3098-3108(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of Rev1 by the Fanconi anemia core complex."Nat. Struct. Mol. Biol. 19:164-170(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic subtyping of Fanconi anemia by comprehensive mutation screening."Hum. Mutat. 29:159-166(2008) [PubMed] [Europe PMC] [Abstract]