Fanconi Anemia Complementation Group F (FANCF)

FANCF was found predominantly in the nucleus, where it complexes with FANCA, FANCC, and FANCG . These interactions were detected in wildtype and FANCD (FANCD2) lymphoblasts, but not in lymphoblasts of other FA complementation groups. The authors hypothesized that each of the FA proteins, except FANCD, is required for complex formation, and that the multiprotein FA complex serves a nuclear function to maintain genomic integrity.FANCF gene encodes a polypeptide with homology to the prokaryotic RNA-binding protein ROM. The region of homology with ROM comprises the N terminus of the prokaryotic protein, which is the region involved in RNA binding. The homologous region in FANCF is predicted to form an alpha-helical structure.