≡

Fanconi Anemia Complementation Group D2 (FANCD2)

[Edit]

FACD; FAD; FANCD; FA-D2; FA4; FAD2

Fanconi Anemia Complementation Group D2 (FANCD2)
CCC K195
HGNC 3585
MGI 2448480
PubMed 11239453
RGD 1303172
UniProt Q9BXW9
Wiki FANCD2
Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, defective DNA repair and enhancement of TNF-alpha production.
FANCD2 encodes the protein for complementation group D2. This protein is monoubiquitinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.A team has shown an in-vitro demonstration of how tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK195Hu01 Recombinant Fanconi Anemia Complementation Group D2 (FANCD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK195Hu01 Polyclonal Antibody to Fanconi Anemia Complementation Group D2 (FANCD2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group D2 (FANCD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group D2 (FANCD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group D2 (FANCD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group D2 (FANCD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group D2 (FANCD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group D2 (FANCD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group D2 (FANCD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fanconi Anemia Complementation Group D2 (FANCD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fanconi Anemia Complementation Group D2 (FANCD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fanconi Anemia Complementation Group D2 (FANCD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fanconi Anemia Complementation Group D2 (FANCD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fanconi Anemia Complementation Group D2 (FANCD2) ELISA Kit Customized Service Offer
  1. "Positional cloning of a novel Fanconi anemia gene, FANCD2."Mol. Cell 7:241-248(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway."Mol. Cell 7:249-262(2001) [PubMed] [Europe PMC] [Abstract]
  6. "S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51."Blood 100:2414-2420(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways."Cell 109:459-472(2002) [PubMed] [Europe PMC] [Abstract]
  8. "FANCE: the link between Fanconi anaemia complex assembly and activity."EMBO J. 21:3414-3423(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems."Blood 102:136-141(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Menin associates with FANCD2, a protein involved in repair of DNA damage."Cancer Res. 63:4204-4210(2003) [PubMed] [Europe PMC] [Abstract]
  11. "FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia."J. Pathol. 201:198-203(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A novel ubiquitin ligase is deficient in Fanconi anemia."Nat. Genet. 35:165-170(2003) [PubMed] [Europe PMC] [Abstract]
  13. "The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways."EMBO J. 23:1178-1187(2004) [PubMed] [Europe PMC] [Abstract]
  14. "BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks."EMBO J. 23:3154-3163(2004) [PubMed] [Europe PMC] [Abstract]
  15. "ATR couples FANCD2 monoubiquitination to the DNA-damage response."Genes Dev. 18:1958-1963(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways."Hum. Mol. Genet. 13:1241-1248(2004) [PubMed] [Europe PMC] [Abstract]
  17. "A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint."J. Biol. Chem. 279:50986-50993(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin."Mol. Cell. Biol. 24:5850-5862(2004) [PubMed] [Europe PMC] [Abstract]
  19. "X-linked inheritance of Fanconi anemia complementation group B."Nat. Genet. 36:1219-1224(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin."Blood 105:1003-1009(2005) [PubMed] [Europe PMC] [Abstract]
  21. "The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability."Hum. Mol. Genet. 14:693-701(2005) [PubMed] [Europe PMC] [Abstract]
  22. "FANCD2 functions independently of BRCA2 and RAD51 associated homologous recombination in response to DNA damage."J. Biol. Chem. 280:14877-14883(2005) [PubMed] [Europe PMC] [Abstract]
  23. "The deubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway."Mol. Cell 17:331-339(2005) [PubMed] [Europe PMC] [Abstract]
  24. "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M."Nat. Genet. 37:958-963(2005) [PubMed] [Europe PMC] [Abstract]
  25. "Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair."Proc. Natl. Acad. Sci. U.S.A. 102:1110-1115(2005) [PubMed] [Europe PMC] [Abstract]
  26. "UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation."Mol. Cell 23:589-596(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair."Cell 129:289-301(2007) [PubMed] [Europe PMC] [Abstract]
  28. "FANCI is a second monoubiquitinated member of the Fanconi anemia pathway."Nat. Struct. Mol. Biol. 14:564-567(2007) [PubMed] [Europe PMC] [Abstract]
  29. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  30. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI."Mol. Cell 32:767-777(2008) [PubMed] [Europe PMC] [Abstract]
  32. "FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3."Oncogene 27:3641-3652(2008) [PubMed] [Europe PMC] [Abstract]
  33. "Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links."Oncogene 27:5045-5056(2008) [PubMed] [Europe PMC] [Abstract]
  34. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  36. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis."Nat. Cell Biol. 11:753-760(2009) [PubMed] [Europe PMC] [Abstract]
  38. "The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities."Nat. Cell Biol. 11:761-768(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2."Cell 142:65-76(2010) [PubMed] [Europe PMC] [Abstract]
  40. "Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents."Cell 142:77-88(2010) [PubMed] [Europe PMC] [Abstract]
  41. "A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair."Mol. Cell 39:36-47(2010) [PubMed] [Europe PMC] [Abstract]
  42. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  43. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  44. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]