Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2)
[Edit]PGL2; SDH5; C11orf79; Paraganglioma Or Familial Glomus Tumors 2
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The SDHAF2 gene encodes a protein necessary for the flavination of the succinate dehydrogenase complex subunit SDHA and thus for SDH activity.
The amino acid sequence of yeast Sdh5 is 44% identical from residues 33 to 158 of 163 to its human ortholog. The human SDH5 gene encodes a highly conserved 167-amino acid protein. Yeast Sdh5 localizes to the mitochondrial matrix. Both yeast and human SDH5 interact with the catalytic subunit of the succinate dehydrogenase complex, a component of both the electron transport chain and the tricarboxylic acid cycle. SDH5 is required for SDH-dependent respiration and for flavination (incorporation of the flavin adenine dinucleotide cofactor) of SDH1 (SDHA).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma."Science 325:1139-1142(2009) [PubMed] [Europe PMC] [Abstract]