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Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18)

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SSXT; SYT

Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18)
CCC K217
HGNC 11340
MGI 107708
PubMed 22439931
RGD 1311919
UniProt Q15532
Wiki SS18
The SYT protein appears to act as a transcriptional coactivator and the SSX proteins as corepressors.SYT also has a C-terminal domain, designated the QPGY domain because it is rich in glutamine, proline, glycine, and tyrosine, that contains the transcriptional activator sequences.
It was found to have been conserved during evolution and to be part of a region of synteny between human and mouse chromosomes 18. In early embryogenesis, mouse Syt is ubiquitously expressed. In later stages, the expression becomes confined to cartilage tissues, specific neuronal cells, and some epithelium-derived tissues. In mature testis, expression was specifically observed in primary spermatocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18) ELISA Kit Customized Service Offer
  1. "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma."Nat. Genet. 7:502-508(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression."Gene 268:173-182(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript."Am. J. Pathol. 147:1592-1599(1995) [PubMed] [Europe PMC] [Abstract]
  5. "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10."Oncogene 20:3281-3289(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator."Endocrinology 146:3892-3899(2005) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]