Inhibitor of DNA Binding Protein 2 (ID2)
[Edit]GIG8; ID2A; ID2H; BHLHB26; Class B basic helix-loop-helix protein 26; Cell Growth-Inhibiting Gene 8; Inhibitor of differentiation 2
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ID2 belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain.
ID2 is able to disrupt the antiproliferative effects of tumor suppressor proteins of the RB family, thus allowing cell cycle progression. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene.This function correlates with the ability of ID2 to associate physically with active, hypophosphorylated forms of the pocket proteins in vitro and in vivo. By inactivating RB, ID2 is also able to abolish the function of another growth inhibitory protein, p16, that operates upstream to RB.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Inhibitor of DNA Binding Protein 2 (ID2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Inhibitor of DNA Binding Protein 2 (ID2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Inhibitor of DNA Binding Protein 2 (ID2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Inhibitor of DNA Binding Protein 2 (ID2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Inhibitor of DNA Binding Protein 2 (ID2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Inhibitor of DNA Binding Protein 2 (ID2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Inhibitor of DNA Binding Protein 2 (ID2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Inhibitor of DNA Binding Protein 2 (ID2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Inhibitor of DNA Binding Protein 2 (ID2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Inhibitor of DNA Binding Protein 2 (ID2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Inhibitor of DNA Binding Protein 2 (ID2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Inhibitor of DNA Binding Protein 2 (ID2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Inhibitor of DNA Binding Protein 2 (ID2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Inhibitor of DNA Binding Protein 2 (ID2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Inhibitor of DNA Binding Protein 2 (ID2) | ELISA Kit Customized Service Offer |
- "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts."J. Biol. Chem. 269:2139-2145(1994) [PubMed] [Europe PMC] [Abstract]
- "A human Id-like helix-loop-helix protein expressed during early development."Proc. Natl. Acad. Sci. U.S.A. 89:1512-1516(1992) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD."Mol. Endocrinol. 18:776-790(2004) [PubMed] [Europe PMC] [Abstract]
- "The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."J. Biol. Chem. 285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]