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NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3)

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C3orf60; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3)
CCC K233
HGNC 29918
MGI 1913956
PubMed 19463981
RGD 708545
UniProt Q9BU61
Wiki 19463981
NDUFAF3 was predominantly localized to mitochondria and remained in the pellet after carbonate extraction, suggesting a strong interaction with the mitochondrial membrane, although NDUFAF3 has no predicted transmembrane helices. Localization appeared identical to that of NDUFAF4. RNA interference studies indicated that the NDUFAF3 gene product is necessary for mitochondrial complex I assembly.
The activity of NDUFAF3 showed functional interdependence with NDUFAF4. Gene conservation analysis linked NDUFAF3 to the bacterial-membrane-insertion gene cluster SecF/SecD/YajC and C8ORF38, suggesting a translation-dependent early assembly mechanism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex Assembly Factor 3 (NDUFaF3) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease."Am. J. Hum. Genet. 84:718-727(2009) [PubMed] [Europe PMC] [Abstract]
  3. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]