≡

RAB6A, Member RAS Oncogene Family (RAB6A)

[Edit]

RAB6

RAB6A, Member RAS Oncogene Family (RAB6A)
CCC K301
HGNC 9786
MGI 894313
PubMed 11929610
RGD 619737
UniProt P20340
Wiki RAB6A
The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion. The predicted human RAB6 protein contains 208 amino acids. Northern blot analysis revealed that the RAB6 gene was expressed as a 3.6-kb mRNA in a human fibroblast cell line.The deduced 208-amino acid protein encoded by this variant differs at only 3 amino acids compared with the previously reported RAB6A isoform.Reexpression of the RAB6A variant in the resistant cell line restored sensitivity to several anticancer drugs. Flow cytometry experiments showed that sensitivity to doxorubicin was associated with increased drug accumulation in cells expressing the RAB6A variant.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB6A, Member RAS Oncogene Family (RAB6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB6A, Member RAS Oncogene Family (RAB6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB6A, Member RAS Oncogene Family (RAB6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB6A, Member RAS Oncogene Family (RAB6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB6A, Member RAS Oncogene Family (RAB6A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB6A, Member RAS Oncogene Family (RAB6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB6A, Member RAS Oncogene Family (RAB6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB6A, Member RAS Oncogene Family (RAB6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB6A, Member RAS Oncogene Family (RAB6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB6A, Member RAS Oncogene Family (RAB6A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB6A, Member RAS Oncogene Family (RAB6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB6A, Member RAS Oncogene Family (RAB6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB6A, Member RAS Oncogene Family (RAB6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB6A, Member RAS Oncogene Family (RAB6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB6A, Member RAS Oncogene Family (RAB6A) ELISA Kit Customized Service Offer
  1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells."J. Cell. Biochem. 79:628-647(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells."Gene 257:67-75(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms."Mol. Biol. Cell 11:3819-3833(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. , Submitted (NOV-2005) to UniProtKB
  9. "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome."EMBO J. 18:1772-1782(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex."Nat. Cell Biol. 4:986-992(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of the human GARP (Golgi associated retrograde protein) complex."Exp. Cell Res. 306:24-34(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic."Exp. Cell Res. 313:3472-3485(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Rab6 family proteins interact with the dynein light chain protein DYNLRB1."Cell Motil. Cytoskeleton 65:183-196(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin." Nat. Genet. 40:1410-1412(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Pitchfork regulates primary cilia disassembly and left-right asymmetry."Dev. Cell 19:66-77(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "A role for the small GTPase Rab6 in assembly of human cytomegalovirus."J. Virol. 85:5213-5219(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Modulation of Rab GTPase function by a protein phosphocholine transferase."Nature 477:103-106(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase."J. Biol. Chem. 287:42129-42137(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance."Am. J. Hum. Genet. 92:955-964(2013) [PubMed] [Europe PMC] [Abstract]
  25. "A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6."PLoS ONE 8:E64149-E64149(2013) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution."J. Struct. Biol. 152:235-238(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185."Cell 132:286-298(2008) [PubMed] [Europe PMC] [Abstract]
  30. "Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain."Structure 17:21-30(2009) [PubMed] [Europe PMC] [Abstract]