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RAB2A, Member RAS Oncogene Family (RAB2A)

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RAB2

RAB2A, Member RAS Oncogene Family (RAB2A)
CCC K302
HGNC 9763
MGI 1928750
PubMed 16189514
RGD 68323
UniProt P61019
Wiki RAB2A
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.
Zahraoui et al. (1989) isolated cDNAs encoding RAB2 and several other human RAB proteins. The predicted 212-amino acid human RAB2 protein shares 98% identity with rat Rab2. Northern blot analysis revealed that the RAB2 gene was expressed as 1.1-, 2.5-, and 3.6-kb mRNAs in a human fibroblast cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB2A, Member RAS Oncogene Family (RAB2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB2A, Member RAS Oncogene Family (RAB2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB2A, Member RAS Oncogene Family (RAB2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB2A, Member RAS Oncogene Family (RAB2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB2A, Member RAS Oncogene Family (RAB2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB2A, Member RAS Oncogene Family (RAB2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB2A, Member RAS Oncogene Family (RAB2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB2A, Member RAS Oncogene Family (RAB2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB2A, Member RAS Oncogene Family (RAB2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB2A, Member RAS Oncogene Family (RAB2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB2A, Member RAS Oncogene Family (RAB2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB2A, Member RAS Oncogene Family (RAB2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB2A, Member RAS Oncogene Family (RAB2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB2A, Member RAS Oncogene Family (RAB2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB2A, Member RAS Oncogene Family (RAB2A) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily."Nucleic Acids Res. 16:10368-10368(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isoprenoid modification of rab proteins terminating in CC or CXC motifs."Proc. Natl. Acad. Sci. U.S.A. 88:6264-6268(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation."J. Biol. Chem. 278:52524-52530(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]