The S. cerevisiae YPT1 and SEC4 genes encode Ras-related GTP-binding proteins involved in the regulation of secretion. Mammalian cells express a large number of RAB proteins, GTP-binding proteins closely related to YPT1 and SEC4. Except for the closely related RAB3A and RAB3B, the deduced human RAB proteins share 32 to 50% homology. The predicted 214-amino acid RAB5 protein is 31% and 38% identical to SEC4 and YPT1, respectively. All 6 human RAB proteins tested bound GTP and exhibited GTPase activities in vitro. Northern blot analysis revealed that RAB5 was expressed as 2.7- and 2.8-kb mRNAs in a human fibroblast cell line. RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPK305Hu01 | Recombinant RAB5A, Member RAS Oncogene Family (RAB5A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAK305Hu21 | Monoclonal Antibody to RAB5A, Member RAS Oncogene Family (RAB5A) | WB; IHC; ICC; IP. |
PAK305Hu01 | Polyclonal Antibody to RAB5A, Member RAS Oncogene Family (RAB5A) | WB; IHC | |
Assay Kits | SEK305Hu | ELISA Kit for RAB5A, Member RAS Oncogene Family (RAB5A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCK305Hu | CLIA Kit for RAB5A, Member RAS Oncogene Family (RAB5A) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPK305Mu01 | Recombinant RAB5A, Member RAS Oncogene Family (RAB5A) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPK305Mu02 | Recombinant RAB5A, Member RAS Oncogene Family (RAB5A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAK305Mu01 | Polyclonal Antibody to RAB5A, Member RAS Oncogene Family (RAB5A) | WB; IHC; ICC; IP. |
PAK305Mu02 | Polyclonal Antibody to RAB5A, Member RAS Oncogene Family (RAB5A) | WB; IHC; ICC; IP. | |
Assay Kits | SEK305Mu | ELISA Kit for RAB5A, Member RAS Oncogene Family (RAB5A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCK305Mu | CLIA Kit for RAB5A, Member RAS Oncogene Family (RAB5A) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RAB5A, Member RAS Oncogene Family (RAB5A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RAB5A, Member RAS Oncogene Family (RAB5A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RAB5A, Member RAS Oncogene Family (RAB5A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RAB5A, Member RAS Oncogene Family (RAB5A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RAB5A, Member RAS Oncogene Family (RAB5A) | ELISA Kit Customized Service Offer |
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