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Myosin VIIA And Rab Interacting Protein (MYRIP)

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MyRIP; SLAC2-C; SLAC2C; Exophilin-8; Synaptotagmin-Like Protein Homologue Lacking C2 Domains-c; Rab Effector MYRIP

Myosin VIIA And Rab Interacting Protein (MYRIP)
CCC K307
HGNC 19156
MGI 2384407
PubMed 20861866
RGD 727731
UniProt Q8NFW9
Mouse Myrip targeted the type II PKA holoenzyme to a specific perinuclear region in insulin-secreting cells. Myrip also interacted with the Sec6 and Sec8 components of the exocyst complex, which controls protein trafficking and exocytosis.
The deduced 856-amino acid protein contains an N-terminal SLP homology domain (SHD) with 2 zinc finger motifs and a C-terminal myosin VA (MYO5A)-binding site. By database analysis, they identified the human ortholog, which encodes a deduced 859-amino acid protein that shares 79.7% identity with mouse Slac2c. RT-PCR analysis of mouse tissues revealed highest expression of Slac2c in brain, lung, and testis, with weaker expression in heart, skeletal muscle, and kidney, and no expression in spleen and liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VIIA And Rab Interacting Protein (MYRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VIIA And Rab Interacting Protein (MYRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VIIA And Rab Interacting Protein (MYRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VIIA And Rab Interacting Protein (MYRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VIIA And Rab Interacting Protein (MYRIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VIIA And Rab Interacting Protein (MYRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VIIA And Rab Interacting Protein (MYRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VIIA And Rab Interacting Protein (MYRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VIIA And Rab Interacting Protein (MYRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VIIA And Rab Interacting Protein (MYRIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VIIA And Rab Interacting Protein (MYRIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VIIA And Rab Interacting Protein (MYRIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VIIA And Rab Interacting Protein (MYRIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VIIA And Rab Interacting Protein (MYRIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VIIA And Rab Interacting Protein (MYRIP) ELISA Kit Customized Service Offer
  1. "MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes."EMBO Rep. 3:463-470(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin."J. Biol. Chem. 277:43096-43103(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "MyRIP anchors protein kinase A to the exocyst complex."J. Biol. Chem. 282:33155-33167(2007) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]