≡

Asparagine Linked Glycosylation Protein 2 (ALG2)

[Edit]

CDGIi; hALPG2; NET38; Alpha-1,3/1,6-mannosyltransferase ALG2; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Asparagine Linked Glycosylation Protein 2 (ALG2)
CCC K324
HGNC 23159
MGI 1914731
PubMed 11278427
RGD 1309940
UniProt Q9H553
Wiki ALG2
ALG2 encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).
By searching databases for homologs of yeast Alg2, Thiel et al. (2003) identified human ALG2. The predicted 416-amino acid ALG2 protein shares 37% identity with yeast Alg2.Thiel et al. (2003) showed that human ALG2 acts as an alpha-1,3-mannosyltransferase. The product of this reaction is further elongated by an alpha-1,6-mannosyltransferase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 2 (ALG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 2 (ALG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 2 (ALG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 2 (ALG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 2 (ALG2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 2 (ALG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 2 (ALG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 2 (ALG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 2 (ALG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 2 (ALG2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 2 (ALG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 2 (ALG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 2 (ALG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 2 (ALG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 2 (ALG2) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis."J. Biol. Chem. 278:22498-22505(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]