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Asparagine Linked Glycosylation Protein 1 (ALG1)

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HMAT1; HMT-1; HMT1; Mannosyltransferase-1; Chitobiosyldiphosphodolichol Beta-Mannosyltransferase,Beta-1,4-Mannosyltransferase

Asparagine Linked Glycosylation Protein 1 (ALG1)
CCC K325
HGNC 18294
MGI 2384774
PubMed 16109369
RGD 1310700
UniProt Q9BT22
Wiki ALG1
The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. Mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.
HMAT1 encodes a 464-amino acid protein that shares 36% amino acid identity with the S. cerevisiae and C. elegans gene products. HMAT1 contains a hydrophobic region at the N terminus followed by short hydrophilic and hydrophobic regions. HMAT1 complemented the temperature-sensitive phenotype of a yeast strain lacking functional MT I due to an ALG1 mutation, indicating that the function of this enzyme is conserved between yeast and human.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 1 (ALG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 1 (ALG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 1 (ALG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 1 (ALG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 1 (ALG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 1 (ALG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 1 (ALG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 1 (ALG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 1 (ALG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 1 (ALG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asparagine Linked Glycosylation Protein 1 (ALG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Asparagine Linked Glycosylation Protein 1 (ALG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Asparagine Linked Glycosylation Protein 1 (ALG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Asparagine Linked Glycosylation Protein 1 (ALG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asparagine Linked Glycosylation Protein 1 (ALG1) ELISA Kit Customized Service Offer
  1. "Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1."Glycobiology 10:321-327(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik."Am. J. Hum. Genet. 74:472-481(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I."Am. J. Hum. Genet. 74:545-551(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik."Hum. Mol. Genet. 13:535-542(2004) [PubMed] [Europe PMC] [Abstract]