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Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3)

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STMP3; TSAP6; Dudlin-2; pHyde; Tumor suppressor-activated pathway protein 6; Metalloreductase STEAP3

Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3)
CCC K330
HGNC 24592
MGI 1915678
PubMed 22031863
RGD 708552
UniProt Q658P3
Wiki STEAP3
Human TSAP6 shares 87% amino acid identity with mouse Tsap6. Northern blot analysis of human tissues detected a 4.3-kb transcript expressed highly in liver and at a lower level in skeletal muscle. Heart, brain, placenta, lung, kidney, and pancreas expressed little to no TSAP6. Northern blot analysis of mouse tissues detected expression predominantly in heart, spleen, lung, liver, and skeletal muscle. Western blot analysis of mouse and human cell lines detected TSAP6 at an apparent molecular mass of 50 to 55 kD.
TSAP6 antisense cDNA decreased the level of p53-induced apoptosis, and TSAP6 small interfering RNA inhibited apoptosis in TSAP6-overexpressing cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 3 (STEAP3) ELISA Kit Customized Service Offer
  1. "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase."Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer."Oncogene 24:4934-4945(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde."Cancer Res. 60:4419-4425(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human pHyde is not a classical tumor suppressor gene in prostate cancer."Int. J. Cancer 106:729-735(2003) [PubMed] [Europe PMC] [Abstract]
  9. "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway."J. Biol. Chem. 279:46104-46112(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global gene repression in hepatocellular carcinoma and fetal liver, and suppression of dudulin-2 mRNA as a possible marker for the cirrhosis-to-tumor transition."J. Hepatol. 42:860-869(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells."Nat. Genet. 37:1264-1269(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The regulation of exosome secretion: a novel function of the p53 protein."Cancer Res. 66:4795-4801(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene."Blood 118:6660-6666(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis."PLoS ONE 7:E37452-E37452(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle."Proc. Natl. Acad. Sci. U.S.A. 105:7410-7415(2008) [PubMed] [Europe PMC] [Abstract]