Glutamate Receptor, Ionotropic, Delta 1 (GRId1)

GRID1 is subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.

The deduced 994-amino acid protein has an N-terminal signal peptide and 4 putative C-terminal transmembrane segments. The putative cytoplasmic domain between transmembrane segments 3 and 4 contains potential phosphorylation sites for calcium/calmodulin-dependent protein kinase II and protein kinase C.The deduced 791-amino acid protein shares 98% identity with mouse Grid1. RT-PCR ELISA detected high expression in adult brain, intermediate expression in fetal brain, low expression in testis and ovary, and no expression in all other peripheral tissues examined.