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Oligosaccharyltransferase Complex Subunit (OSTC)

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DC2; Hydrophobic protein HSF-28; Oligosaccharyltransferase complex subunit OSTC

Oligosaccharyltransferase Complex Subunit (OSTC)
CCC K355
HGNC 24448
MGI 1913607
PubMed 21310313
RGD 1560708
UniProt Q9NRP0
The enzyme that catalyzes this process is a heteromeric, multisubunit membrane complex, called oligosaccharyltransferase () . Purification of OST from yeast and genetic methods identified nine proteins. Five of them, Wbp1, Swp1, Stt3, Ost1, and Ost2, are essential for viability of the cell, whereas Ost4, Ost5, Ost3, and Ost6 are not essential but are required for maximal OST activity. The specific function of the various subunits and the organization in the complex is largely enigmatic. Subunits Ost3 and Ost6 are alternatively present in the yeast OST complex; they modify the transfer specificity toward protein to be glycosylated and they specify the interaction with different translocation complexes. In mammals, two OST complexes exist that contain either one of two isoforms of Stt3, which display tissue-specific expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oligosaccharyltransferase Complex Subunit (OSTC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oligosaccharyltransferase Complex Subunit (OSTC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oligosaccharyltransferase Complex Subunit (OSTC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oligosaccharyltransferase Complex Subunit (OSTC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oligosaccharyltransferase Complex Subunit (OSTC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oligosaccharyltransferase Complex Subunit (OSTC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oligosaccharyltransferase Complex Subunit (OSTC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oligosaccharyltransferase Complex Subunit (OSTC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oligosaccharyltransferase Complex Subunit (OSTC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oligosaccharyltransferase Complex Subunit (OSTC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oligosaccharyltransferase Complex Subunit (OSTC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oligosaccharyltransferase Complex Subunit (OSTC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oligosaccharyltransferase Complex Subunit (OSTC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oligosaccharyltransferase Complex Subunit (OSTC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oligosaccharyltransferase Complex Subunit (OSTC) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]