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Calcium Homeostasis Modulator 1 (CALHM1)

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FAM26C; Family With Sequence Similarity 26,Member C

Calcium Homeostasis Modulator 1 (CALHM1)
CCC K361
HGNC 23494
MGI 3643383
PubMed 23467090
RGD 1564891
UniProt Q8IU99
Wiki CALHM1
CALHM1 encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear. The deduced 346-amino acid CALHM1 protein contains a hydrophobic loop that does not cross the membrane, 3 transmembrane segments, and 2 putative N-glycosylation sites. RT-PCR detected highest CALHM1 expression in whole adult brain, spinal cord, and all adult brain regions examined, with much lower expression in all other tissues examined, including fetal brain. Immunohistochemical analysis revealed that CALHM1 localized to the endoplasmic reticulum (ER) and plasma membrane in transfected cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Homeostasis Modulator 1 (CALHM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Homeostasis Modulator 1 (CALHM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Homeostasis Modulator 1 (CALHM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Homeostasis Modulator 1 (CALHM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Homeostasis Modulator 1 (CALHM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Homeostasis Modulator 1 (CALHM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Homeostasis Modulator 1 (CALHM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Homeostasis Modulator 1 (CALHM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Homeostasis Modulator 1 (CALHM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Homeostasis Modulator 1 (CALHM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Homeostasis Modulator 1 (CALHM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Homeostasis Modulator 1 (CALHM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Homeostasis Modulator 1 (CALHM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Homeostasis Modulator 1 (CALHM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Homeostasis Modulator 1 (CALHM1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk." Cell 133:1149-1161(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations."PLoS ONE 4:E7682-E7682(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Calcium homoeostasis modulator 1 (CALHM1) reduces the calcium content of the endoplasmic reticulum (ER) and triggers ER stress."Biochem. J. 437:469-475(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability."Proc. Natl. Acad. Sci. U.S.A. 109:E1963-E1971(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins."J. Biol. Chem. 288:6140-6153(2013) [PubMed] [Europe PMC] [Abstract]
  8. "CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons."J. Cell Sci. 126:1199-1206(2013) [PubMed] [Europe PMC] [Abstract]
  9. "CALHM1 polymorphism is not associated with late-onset Alzheimer disease."Ann. Hum. Genet. 73:379-381(2009) [PubMed] [Europe PMC] [Abstract]
  10. "No association between CALHM1 and Alzheimer's disease risk."Cell 135:993-994(2008) [PubMed] [Europe PMC] [Abstract]
  11. "No association between CALHM1 variation and risk of Alzheimer disease."Hum. Mutat. 30:E566-E569(2009) [PubMed] [Europe PMC] [Abstract]
  12. "No association between CALHM1 and risk for Alzheimer dementia in a Belgian population."Hum. Mutat. 30:E570-E574(2009) [PubMed] [Europe PMC] [Abstract]
  13. "CALHM1 variant is not associated with Alzheimer's disease among Asians."Neurobiol. Aging 32:546.E11-546.E12(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The P86L common allele of CALHM1 does not influence risk for Alzheimer disease in Japanese cohorts."Am. J. Med. Genet. B Neuropsychiatr. Genet. 153:532-535(2010) [PubMed] [Europe PMC] [Abstract]
  15. "CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population."J. Alzheimers Dis. 19:31-35(2010) [PubMed] [Europe PMC] [Abstract]
  16. "CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model."J. Alzheimers Dis. 20:247-251(2010) [PubMed] [Europe PMC] [Abstract]
  17. "The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study." J. Alzheimers Dis. 22:247-255(2010) [PubMed] [Europe PMC] [Abstract]
  18. "No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population."Psychiatr. Genet. 21:249-252(2011) [PubMed] [Europe PMC] [Abstract]