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Butyrophilin Subfamily 3, Member A1 (BTN3A1)

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CD277; BT3.1; BTF5

Butyrophilin Subfamily 3, Member A1 (BTN3A1)
CCC K379
HGNC 1138
PubMed 9149941
UniProt O00481
Wiki BTN3A1
The butyrophilins (BTN) belong to the Ig superfamily, and are encoded in a cluster of seven genes in the extended MHC class I region on chromosome 6 . BTN1, BTN2, and BTN3 subfamilies share 50% amino acid identity. The extracellular domains of the three members within each subfamily are more closely related and share 88% (BTN2A1, -A2 and -A3) and 95% (BTN3A1, -A2 and -A3) identity, respectively.
BTN1, the prototype of the family, is a major component of the milk fat globule membrane and is regulated by lactogenic hormones. BTN1 has a crucial function in the secretion of lipids into milk. Collectively, BTN2 and BTN3 are cell surface transmembrane glycoproteins, transcripts of which are ubiquitously expressed at a low to intermediate level.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK379Hu01 Recombinant Butyrophilin Subfamily 3, Member A1 (BTN3A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Butyrophilin Subfamily 3, Member A1 (BTN3A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Butyrophilin Subfamily 3, Member A1 (BTN3A1) Polyclonal Antibody Customized Service Offer
Assay Kits SEK379Hu ELISA Kit for Butyrophilin Subfamily 3, Member A1 (BTN3A1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex."Immunogenetics 47:55-63(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A 1.1-Mb transcript map of the hereditary hemochromatosis locus."Genome Res. 7:441-456(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity."J. Leukoc. Biol. 88:757-767(2010) [PubMed] [Europe PMC] [Abstract]
  7. "CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells."Oncotarget 1:329-338(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Differential role for CD277 as a co-regulator of the immune signal in T and NK cells."Eur. J. Immunol. 41:3443-3454(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset."Blood 120:2269-2279(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies."J. Biol. Chem. 287:32780-32790(2012) [PubMed] [Europe PMC] [Abstract]