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T-Cell Activation Antigen, Increased Late Expression (TACTILE)

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CD96; T-cell surface protein tactile

T-Cell Activation Antigen, Increased Late Expression (TACTILE)
CCC K382
HGNC 16892
MGI 1934368
PubMed 11249296
RGD 1565249
UniProt P40200
Wiki Tactile
Sequence analysis predicted that the 569-amino acid TACTILE protein is a member of the immunoglobulin superfamily. TACTILE contains a signal peptide; an extracellular region with 15 N-linked glycosylation sites and a 132-residue stretch rich in serine, threonine, and proline, a characteristic of domains with extensive O-linked glycosylation; a transmembrane domain; and a 45-amino acid cytoplasmic domain.
Immunoprecipitation and immunoblot analyses showed that both recombinant and native TACTILE proteins are expressed as 160-kD proteins under reducing conditions. Northern blot analysis revealed expression of a major 4.4- and a minor 2.4-kb TACTILE transcript in cell lines that also express the TACTILE protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Activation Antigen, Increased Late Expression (TACTILE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Activation Antigen, Increased Late Expression (TACTILE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Activation Antigen, Increased Late Expression (TACTILE) Polyclonal Antibody Customized Service Offer
Assay Kits SEK382Hu ELISA Kit for T-Cell Activation Antigen, Increased Late Expression (TACTILE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Activation Antigen, Increased Late Expression (TACTILE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Activation Antigen, Increased Late Expression (TACTILE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Activation Antigen, Increased Late Expression (TACTILE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Activation Antigen, Increased Late Expression (TACTILE) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Activation Antigen, Increased Late Expression (TACTILE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Activation Antigen, Increased Late Expression (TACTILE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Activation Antigen, Increased Late Expression (TACTILE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Activation Antigen, Increased Late Expression (TACTILE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Activation Antigen, Increased Late Expression (TACTILE) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Activation Antigen, Increased Late Expression (TACTILE) ELISA Kit Customized Service Offer
  1. "Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily."J. Immunol. 148:2600-2608(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)."J. Immunol. 172:3994-3998(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome."Am. J. Hum. Genet. 81:835-841(2007) [PubMed] [Europe PMC] [Abstract]