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Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1)

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CXXC6; LCX; Leukemia-Associated Protein With A CXXC Domain; CXXC Finger 6; Ten Eleven Translocation 1; Tet Methylcytosine Dioxygenase 1; Tet Oncogene Family, Member 1

Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1)
CCC K405
HGNC 29484
MGI 1098693
PubMed 23151479
UniProt Q8NFU7
Wiki TET1
TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethycytosine (hmC) in cultured cells and in vitro. hmC is present in the genome of mouse embryonic stem cells, and hmC levels decrease upon RNA interference-mediated depletion of TET1.LCX gene encodes a 2,136-amino acid protein with a zinc-binding CXXC domain (which MLL also contains) within a methyltransferase domain, 3 nuclear localizations signals, and an alpha-helical coiled-coil region. The MLL-LCX fusion protein lacked a CXXC domain of LCX, but retained an alpha-helical coiled-coil region at the C terminus, similar to MLL-AF6, MLL-AF1P, and other fusion proteins involved in the pathogenesis of 11q23-associated leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ten-Eleven Translocation Methylcytosine Dioxygenase 1 (TET1) ELISA Kit Customized Service Offer
  1. "LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)."Cancer Res. 62:4075-4080(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)."Leukemia 17:637-641(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain."Science 324:929-930(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by the MLL fusion partner TET1."Science 324:930-935(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."Cell 145:423-434(2011) [PubMed] [Europe PMC] [Abstract]
  10. "TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity."Nature 473:343-348(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine."Science 333:1300-1303(2011) [PubMed] [Europe PMC] [Abstract]