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Conserved Helix Loop Helix Ubiquitous Kinase (CHUK)

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TCF16; IKK1; IKK-alpha; IkBKA; NFKBIKA; IKKA; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Transcription factor 16; I-kappa-B kinase 1

Conserved Helix Loop Helix Ubiquitous Kinase (CHUK)
CCC K407
HGNC 1974
MGI 99484
PubMed 8777433
RGD 1306661
UniProt O15111
Wiki IKKA
NFKB1 or NFKB2 is bound to REL, RELA , or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex.
CHUK contains a serine/threonine kinase domain; due to its ubiquitous expression in a broad array of tissues and high degree of conservation across species, it was designated CHUK for 'conserved helix-loop-helix ubiquitous kinase.' The multidomain polypeptide encoded by the CHUK gene also contains leucine zipper motifs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Polyclonal Antibody Customized Service Offer
Assay Kits SEK407Hu ELISA Kit for Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Enzyme-linked immunosorbent assay for Antigen Detection.
HEK407Hu High Sensitive ELISA Kit for Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Conserved Helix Loop Helix Ubiquitous Kinase (CHUK) ELISA Kit Customized Service Offer
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  10. "NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase."Nature 401:82-85(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation."Science 284:309-313(1999) [PubMed] [Europe PMC] [Abstract]
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  14. "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase."Mol. Cell. Biol. 22:3549-3561(2002) [PubMed] [Europe PMC] [Abstract]
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  16. "Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression."Nature 423:655-659(2003) [PubMed] [Europe PMC] [Abstract]
  17. "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages."J. Biol. Chem. 279:51897-51907(2004) [PubMed] [Europe PMC] [Abstract]
  18. "beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha."Proc. Natl. Acad. Sci. U.S.A. 101:8603-8607(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus."Nature 437:1167-1172(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity."Cell 129:903-914(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB."Mol. Cell 26:75-87(2007) [PubMed] [Europe PMC] [Abstract]
  22. "The IkappaB kinase complex: master regulator of NF-kappaB signaling."Immunol. Res. 42:3-18(2008) [PubMed] [Europe PMC] [Abstract]
  23. "SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression."J. Biol. Chem. 284:4073-4089(2009) [PubMed] [Europe PMC] [Abstract]
  24. "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways."Cell 141:483-496(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Mutant CHUK and severe fetal encasement malformation."N. Engl. J. Med. 363:1631-1637(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation."Sci. Signal. 3:RA41-RA41(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1."Nat. Immunol. 12:834-843(2011) [PubMed] [Europe PMC] [Abstract]
  29. "The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling."J. Biol. Chem. 287:42856-42866(2012) [PubMed] [Europe PMC] [Abstract]
  30. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  31. "Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site."Structure 16:798-808(2008) [PubMed] [Europe PMC] [Abstract]