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Podolski et al. (2001) described a reciprocal, balanced, constitutional chromosome translocation, t(2;3)(q33;q21), that is associated with familial clear cell renal cancer. The gene, designated DIRC1 (disrupted in renal cancer-1), was disrupted between exons 1 and 2 by the familial translocation. The 1.5-kb DIRC1 mRNA encoded an 11-kD predicted protein of 104 amino acids. RT-PCR analysis detected low-level expression of DIRC1 in adult placenta, testis, ovary, and prostate, and in fetal kidney, spleen, and skeletal muscle. Two familial tumors showed loss of the derivative chromosome 3, as observed in a Dutch kindred with t(2;3)-associated renal cancers in a Dutch family. Druck et al. (2001) concluded that further studies were necessary to determine if inactivation of the gene contributes to the development of familial cancers.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Disrupted In Renal Carcinoma 1 (DIRC1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Disrupted In Renal Carcinoma 1 (DIRC1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Disrupted In Renal Carcinoma 1 (DIRC1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Disrupted In Renal Carcinoma 1 (DIRC1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Disrupted In Renal Carcinoma 1 (DIRC1) | ELISA Kit Customized Service Offer |
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