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Dicer 1, Ribonuclease Type III (DICER1)

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Dicer; HERNA; Dicer 1,Double-Stranded RNA-Specific Endoribonuclease; Helicase with RNase motif; Helicase MOI

Dicer 1, Ribonuclease Type III (DICER1)
CCC K448
HGNC 17098
MGI 2177178
PubMed 21266384
RGD 1309381
UniProt Q9UPY3
Wiki DICER1
DICER1 encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene.A 2.1-kb clone contained a partial cDNA of a human protein with high homology to the hypothetical helicase K12H4.8 from C. elegans. Analysis of the predicted amino acid sequence revealed the presence of an RNase III motif and a double-stranded RNA (dsRNA)-binding domain, indicative of a protein of nuclear origin. C. elegans K12H4.8 and the human homolog share 58% identity over 275 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK448Hu01 Recombinant Dicer 1, Ribonuclease Type III (DICER1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK448Hu01 Polyclonal Antibody to Dicer 1, Ribonuclease Type III (DICER1) WB; IHC; ICC; IP.
MAK448Hu21 Monoclonal Antibody to Dicer 1, Ribonuclease Type III (DICER1) WB; IHC; ICC; IP.
Assay Kits SEK448Hu ELISA Kit for Dicer 1, Ribonuclease Type III (DICER1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dicer 1, Ribonuclease Type III (DICER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dicer 1, Ribonuclease Type III (DICER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dicer 1, Ribonuclease Type III (DICER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dicer 1, Ribonuclease Type III (DICER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dicer 1, Ribonuclease Type III (DICER1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dicer 1, Ribonuclease Type III (DICER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dicer 1, Ribonuclease Type III (DICER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dicer 1, Ribonuclease Type III (DICER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dicer 1, Ribonuclease Type III (DICER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dicer 1, Ribonuclease Type III (DICER1) ELISA Kit Customized Service Offer
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  10. "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer."EMBO Rep. 5:189-194(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."Cell 123:631-640(2005) [PubMed] [Europe PMC] [Abstract]
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  13. "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."EMBO Rep. 6:961-967(2005) [PubMed] [Europe PMC] [Abstract]
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  15. "TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."Nature 436:740-744(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The role of PACT in the RNA silencing pathway."EMBO J. 25:522-532(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."J. Biol. Chem. 282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]
  18. "RNA helicase A interacts with RISC in human cells and functions in RISC loading."Mol. Cell 26:523-537(2007) [PubMed] [Europe PMC] [Abstract]
  19. "MicroRNA silencing through RISC recruitment of eIF6."Nature 447:823-828(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Prolyl 4-hydroxylation regulates Argonaute 2 stability."Nature 455:421-424(2008) [PubMed] [Europe PMC] [Abstract]
  21. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  22. "In vitro reconstitution of the human RISC-loading complex."Proc. Natl. Acad. Sci. U.S.A. 105:512-517(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  24. "A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function."Nat. Genet. 41:365-370(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Extending the phenotypes associated with DICER1 mutations."Hum. Mutat. 32:1381-1384(2011) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Human RNA methyltransferase BCDIN3D regulates microRNA processing."Cell 151:278-288(2012) [PubMed] [Europe PMC] [Abstract]
  29. "Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers." N. Engl. J. Med. 366:234-242(2012) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  31. "Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer."J. Mol. Biol. 374:106-120(2007) [PubMed] [Europe PMC] [Abstract]
  32. "DICER1 mutations in familial pleuropulmonary blastoma."Science 325:965-965(2009) [PubMed] [Europe PMC] [Abstract]
  33. "DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors." JAMA 305:68-77(2011) [PubMed] [Europe PMC] [Abstract]