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Unc-45 Homolog A (UNC45A)

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SMAP-1; GC-UNC45; Smooth Muscle Cell Associated Protein-1

Unc-45 Homolog A (UNC45A)
CCC K472
HGNC 30594
MGI 2142246
PubMed 19843631
RGD 1305357
UniProt Q9H3U1
Wiki UNC45A
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR) and HSP90 (HSPCA), and acts as a regulator of the progesterone receptor chaperoning pathway.
UNC45A contains an N-terminal triple TPR motif, a unique central region, and a C-terminal UNC45/Cro1/She4p (UCS) domain. EST database searches showed human UNC45A expression over a wide range of tissues. The authors also clone mouse Unc45a, and Northern blot analysis of mouse tissues detected Unc45a expression in uterus, large intestine, kidney, spleen, lung, brain, liver, and ovary, with slightly lower levels in cardiac and skeletal muscle compared to nonstriated muscle tissues. Unc45a expression was detected in 12-day-old whole mouse embryos and in over 12 tumor types.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-45 Homolog A (UNC45A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-45 Homolog A (UNC45A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-45 Homolog A (UNC45A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-45 Homolog A (UNC45A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-45 Homolog A (UNC45A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-45 Homolog A (UNC45A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-45 Homolog A (UNC45A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-45 Homolog A (UNC45A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-45 Homolog A (UNC45A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-45 Homolog A (UNC45A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-45 Homolog A (UNC45A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-45 Homolog A (UNC45A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-45 Homolog A (UNC45A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-45 Homolog A (UNC45A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-45 Homolog A (UNC45A) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, characterization and chromosome mapping of the human SMAP1 gene."Gene 292:167-171(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The solution structure of the tetratricopeptide repeat of human smooth muscle cell associated protein-1."Submitted (JUN-2006) to the PDB data bank
  11. "GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."Mol. Cell. Biol. 26:1722-1730(2006) [PubMed] [Europe PMC] [Abstract]