Clostebol, usually as the ester clostebol acetate or clostebol enanthate, is a synthetic anabolic androgenic steroid. Clostebol is the 4-chloro derivative of the natural hormone testosterone. It is a weak anabolic steroid which was used by athletes from the German Democratic Republic (East Germany).[citation needed] It is a version of testosterone that is chlorinated so as to prevent conversion to dihydrotestosterone (DHT) while also rendering the chemical incapable of conversion to estrogen. Seven metabolites of 4-chlorotestosterone acetate were identified in urine of cattle that received a single injection of the drug. The steroids were isolated by means of a series of clean-up steps carried out before and after enzymatic hydrolysis. The illegal use of 4-chlorotestosterone acetate can be detected by identifying one or more of its metabolites in urine.
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