1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphocholine (POPC)

POPC is a chemical compound. It is a diacylglycerol and phospholipid. The full name is 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine. It is an important lipid for biophysical experiments and has been used to study various subjects such as lipid rafts. It is available commercially synthetically and is naturally present in eukaryotic cell membranes.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho) (1 microM) enhanced long-term depression (LTD), a synaptic plasticity relevant to learning and memory, in the CA1 region of rat hippocampal slices, where expression of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluR1 on the plasma membrane was decreased. POPhtCho could ameliorate cognitive disorders, possibly by enhancing LTD.