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Alstrom Syndrome Protein 1 (ALMS1)

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Alstrom Syndrome Protein 1 (ALMS1)
CCC L066
HGNC 428
MGI 1934606
PubMed 17206865
RGD 1311590
UniProt Q8TCU4
Wiki ALMS1
ALMS1 is located on the short arm of chromosome 2 (2p13.2) on the plus (Watson) strand. It is 224,161 bases in length organised into 23 exons. The encoded protein has 4,167 amino acids and molecular weight of 460,937 Da. Three isofoms are known. The protein itself has a large tandem-repeat domain comprising 34 imperfect repetitions of 47 amino acids.
The gene is expressed in fetal tissues including the aorta, brain, eye, kidney, liver, lung, olfactory bulb, pancreas, skeletal muscle, spleen and testis. The protein is found in the cytoplasm, centrosome, cell projections and cilium basal body. During mitosis it localizes to both spindle poles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alstrom Syndrome Protein 1 (ALMS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alstrom Syndrome Protein 1 (ALMS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alstrom Syndrome Protein 1 (ALMS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alstrom Syndrome Protein 1 (ALMS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alstrom Syndrome Protein 1 (ALMS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alstrom Syndrome Protein 1 (ALMS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alstrom Syndrome Protein 1 (ALMS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alstrom Syndrome Protein 1 (ALMS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alstrom Syndrome Protein 1 (ALMS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alstrom Syndrome Protein 1 (ALMS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alstrom Syndrome Protein 1 (ALMS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alstrom Syndrome Protein 1 (ALMS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alstrom Syndrome Protein 1 (ALMS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alstrom Syndrome Protein 1 (ALMS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alstrom Syndrome Protein 1 (ALMS1) ELISA Kit Customized Service Offer
  1. "Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alstrom syndrome."Nat. Genet. 31:79-83(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome."Nat. Genet. 31:74-78(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes."Diabetes 54:1581-1587(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Cep164, a novel centriole appendage protein required for primary cilium formation."J. Cell Biol. 179:321-330(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731."Mol. Biol. Cell 21:3617-3629(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]