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MutS Homolog 3 (MSH3)

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MRP1; DUP; Divergent Upstream Protein; Mismatch Repair Protein 1; DNA mismatch repair protein Msh3

MutS Homolog 3 (MSH3)
CCC L067
HGNC 7326
MGI 109519
PubMed 23209772
RGD 1563954
UniProt P20585
Wiki MSH3
MSH3 forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. Defects in this gene are a cause of susceptibility to endometrial cancer.
MSH3 mRNA was not detectable in 7 cases, including 3 of chronic myelogenous leukemia, 2 of acute myelogeneous leukemia, 1 of acute lymphocytic leukemia, and 1 of myelodysplastic syndrome. In addition, 17 cases showed significantly reduced expression of the MSH3 gene. These results suggested to the authors that inactivation of the MSH3 gene may be involved in the development of hematologic malignancies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutS Homolog 3 (MSH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutS Homolog 3 (MSH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutS Homolog 3 (MSH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutS Homolog 3 (MSH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutS Homolog 3 (MSH3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutS Homolog 3 (MSH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutS Homolog 3 (MSH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutS Homolog 3 (MSH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutS Homolog 3 (MSH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutS Homolog 3 (MSH3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MutS Homolog 3 (MSH3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MutS Homolog 3 (MSH3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MutS Homolog 3 (MSH3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MutS Homolog 3 (MSH3) CLIA Kit Customized Service Offer
n/a ELISA Kit for MutS Homolog 3 (MSH3) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene."J. Biol. Chem. 264:10057-10064(1989) [PubMed] [Europe PMC] [Abstract]
  2. "hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6."Proc. Natl. Acad. Sci. U.S.A. 93:13629-13634(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The interaction of DNA mismatch repair proteins with human exonuclease I."J. Biol. Chem. 276:33011-33018(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Nine-bp repeat polymorphism in exon 1 of the hMSH3 gene."Jpn. J. Hum. Genet. 40:343-345(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability."J. Hum. Genet. 45:228-230(2000) [PubMed] [Europe PMC] [Abstract]