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Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4)

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RPF1; PIG53; Receptor-Potentiating Factor 1; E3 ubiquitin-protein ligase NEDD4; Cell proliferation-inducing gene 53 protein

Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4)
CCC L073
HGNC 7727
MGI 97297
PubMed 24158909
RGD 3157
UniProt P46934
Wiki NEDD4
Nedd4 is expressed in various other embryonic tissues and persists in most adult tissues.Nedd4 protein is localized to the cellular cytoplasm. the human NEDD4 protein has 86% amino acid identity with the mouse protein. It has homology to ubiquitin-protein ligases and contains 4 protein-protein interaction (WW) domains and a calcium/phospholipid binding domain.The deduced protein has a C2 domain and is homologous with mouse Nedd4, with which it shares 84% identity. Northern blot analysis detected NEDD4 in all tissues and cell lines examined, except brain.NEDD4 could also positively regulate PTEN through monoubiquitination of PTEN in human and mouse cells. Monoubiquitinated PTEN was stabilized by its accumulation in cell nuclei, and it retained its ability to antagonize AKT (AKT1) and cause apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 4 (NEDD4) ELISA Kit Customized Service Offer
  1. "NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN."Cell 128:129-139(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF."J. Biol. Chem. 276:46995-47003(2001) [PubMed] [Europe PMC] [Abstract]
  8. "PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101."J. Virol. 77:11882-11895(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins."J. Biol. Chem. 283:32621-32627(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity."Proc. Natl. Acad. Sci. U.S.A. 105:3974-3979(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization."Proc. Natl. Acad. Sci. U.S.A. 105:8585-8590(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK."Mol. Cell. Biol. 30:1541-1554(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development."Neuron 65:358-372(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function."EMBO J. 30:3259-3273(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression."Oncogene 31:4599-4608(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of the C2 domain of the E3 ubiquitin-protein ligase Nedd4."Submitted (OCT-2007) to the PDB data bank
  21. "Human NEDD4 3rd WW domain complex with ebola Zaire virus matrix protein VP40 derived peptide."Submitted (OCT-2009) to the PDB data bank
  22. "Human NEDD4 3rd WW domain complex with human T-cell leukemia virus GAP-Pro polyprotein derived peptide."Submitted (OCT-2009) to the PDB data bank
  23. "Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation."EMBO Rep. 12:342-349(2011) [PubMed] [Europe PMC] [Abstract]
  24. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]