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Topoisomerase I Binding, Arginine/Serine Rich (TOPORS)

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LUN; TP53BPL; p53BP3; RP31; Retinitis Pigmentosa 31; SUMO1-protein E3 ligase Topors; Tumor suppressor p53-binding protein 3; E3 ubiquitin-protein ligase Topors

Topoisomerase I Binding, Arginine/Serine Rich (TOPORS)
CCC L086
HGNC 21653
MGI 2146189
PubMed 15247280
RGD 1305270
UniProt Q9NS56
Wiki TOPORS
TOPORS is rich in serine and arginine and contains a leucine zipper domain, 2 PEST sequences, a central basic domain containing 2 potential bipartite nuclear localization signals, and 2 C-terminal PEST sequences.
The deduced 1,045-amino acid protein has a calculated molecular mass of 119 kD. TOPORS contains an N-terminal PEST sequence, followed by a C3H4-type RING finger domain, a leucine zipper coiled-coil region, 2 PEST sequences, a nuclear localization signal, and 2 C-terminal PEST sequences. Northern blot analysis detected a 3.8-kb transcript in brain, kidney, liver, lung, spleen, pancreas, and skeletal muscle, and a 3.6-kb transcript in heart and lung. Highest expression of TOPORS was in lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Topoisomerase I Binding, Arginine/Serine Rich (TOPORS) ELISA Kit Customized Service Offer
  1. "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein."Nucleic Acids Res. 27:2538-2544(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of LUN, a novel RING-finger protein that is highly expressed in lung and specifically binds to a palindromic sequence."J. Biol. Chem. 276:14004-14013(2001) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a novel gene encoding a p53-associated protein."Gene 235:93-101(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies."Exp. Cell Res. 277:152-160(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation."Exp. Cell Res. 290:13-27(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53."J. Biol. Chem. 279:36440-36444(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer."Lung Cancer 46:21-28(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor."Oncogene 23:5293-5300(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo."FEBS Lett. 579:5007-5012(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage."Oncogene 24:3385-3396(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy." Am. J. Hum. Genet. 81:1098-1103(2007) [PubMed] [Europe PMC] [Abstract]
  14. "TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins."J. Proteome Res. 6:3918-3923(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity."Biochemistry 47:13887-13896(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1."J. Biol. Chem. 283:4834-4840(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Plk1-mediated phosphorylation of Topors regulates p53 stability."J. Biol. Chem. 284:18588-18592(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death."Mol. Cell 37:503-515(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]