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Programmed Cell Death Protein 4 (PDCD4)

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H731; Neoplastic Transformation Inhibitor; Nuclear antigen H731-like; Protein 197/15a

Programmed Cell Death Protein 4 (PDCD4)
CCC L108
HGNC 8763
MGI 107490
PubMed 23758151
RGD 620816
UniProt Q53EL6
Wiki PDCD4
PDCD4 encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.The deduced 458-amino acid protein has a calculated molecular mass of 50.6 kD. PDCD4 is an acidic protein with characteristics of a nuclear nonhistone protein. It contains 2 overlapping GxGxxG nucleotide-binding motifs, which are characteristic of protein kinases, but it does not have a kinase catalytic domain. PDCD4 also has several putative serine and threonine phosphorylation sites. Northern blot analysis detected transcripts of about 2.7 and 3.8 kb in HeLa cell total RNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Programmed Cell Death Protein 4 (PDCD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Programmed Cell Death Protein 4 (PDCD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Programmed Cell Death Protein 4 (PDCD4) Polyclonal Antibody Customized Service Offer
Assay Kits SEL108Hu ELISA Kit for Programmed Cell Death Protein 4 (PDCD4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Programmed Cell Death Protein 4 (PDCD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Programmed Cell Death Protein 4 (PDCD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Programmed Cell Death Protein 4 (PDCD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 4 (PDCD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 4 (PDCD4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Programmed Cell Death Protein 4 (PDCD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Programmed Cell Death Protein 4 (PDCD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Programmed Cell Death Protein 4 (PDCD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 4 (PDCD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 4 (PDCD4) ELISA Kit Customized Service Offer
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  2. "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells."J. Immunol. 161:3493-3500(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody."Pathol. Int. 49:1067-1077(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis."J. Pathol. 200:640-646(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Akt phosphorylates and regulates Pdcd4 tumor suppressor protein."Cancer Res. 65:11282-11286(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion."Mol. Cell. Biol. 26:1297-1306(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  14. "S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth."Science 314:467-471(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the MA3 domain of human programmed cell death 4."Submitted (APR-2007) to the PDB data bank
  22. "PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains."Proc. Natl. Acad. Sci. U.S.A. 105:3274-3279(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for translational inhibition by the tumour suppressor Pdcd4."EMBO J. 28:274-285(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the eIF4A-PDCD4 complex."Proc. Natl. Acad. Sci. U.S.A. 106:3148-3153(2009) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]