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Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1)

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MFD1; Treacle

Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1)
CCC L125
HGNC 11654
MGI 892003
PubMed 22317976
RGD 1309850
UniProt Q13428
Wiki TCOF1
TCOF1encodes a nucleolar protein with an LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only three of them have been characterized to date. TCOF1 is a gene that provides instructions for making a protein called treacle. This protein is active during early embryonic development in structures that become bones and other tissues in the face. Although the precise function of this protein is unknown, researchers believe that it plays a critical role in the development of facial bones and related structures.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Treacher Collins Franceschetti Syndrome Protein 1 (TCOF1) ELISA Kit Customized Service Offer
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  11. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  12. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
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  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon."Am. J. Hum. Genet. 60:515-524(1997) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]