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CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2)

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C48; Cep215; MCPH3; Microcephaly,Primary Autosomal Recessive 3; Centrosome-associated protein 215

CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2)
CCC L132
HGNC 18672
MGI 2384875
PubMed 21135143
RGD 708451
UniProt Q96SN8
Wiki CDK5RAP2
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. CDK5RAP2 binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein may also be a substrate of neuronal CDC2-like kinase. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.The deduced protein contains 1,561 amino acids. RT-PCR ELISA detected moderate to high expression of CDK5RAP2 in all tissues and specific brain regions examined. Highest levels were detected in skeletal muscle, fetal liver, brain, kidney, and ovary. Within specific brain regions, highest expression was detected in thalamus, corpus callosum, substantia nigra, hippocampus, and caudate nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) ELISA Kit Customized Service Offer
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  9. ErratumNat. Genet. 37:555-555(2005)
  10. "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion."J. Cell Sci. 120:4321-4331(2007) [PubMed] [Europe PMC] [Abstract]
  11. "CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex."Mol. Biol. Cell 19:115-125(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "CDK5RAP2 is required for spindle checkpoint function."Cell Cycle 8:1206-1216(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics."Mol. Biol. Cell 20:3660-3670(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components."PLoS ONE 4:E5976-E5976(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex."J. Biol. Chem. 285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]