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ErbB2 Interacting Protein (ERBB2IP)

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LAP2; ERBIN; Densin-180-Like Protein; ERBB2-Interacting Protein

ErbB2 Interacting Protein (ERBB2IP)
CCC L144
HGNC 15842
MGI 1890169
PubMed 24812403
UniProt Q96RT1
Wiki Erbin
ERBB2IPcontains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.
Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis. Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ErbB2 Interacting Protein (ERBB2IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ErbB2 Interacting Protein (ERBB2IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ErbB2 Interacting Protein (ERBB2IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ErbB2 Interacting Protein (ERBB2IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ErbB2 Interacting Protein (ERBB2IP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ErbB2 Interacting Protein (ERBB2IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ErbB2 Interacting Protein (ERBB2IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ErbB2 Interacting Protein (ERBB2IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ErbB2 Interacting Protein (ERBB2IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for ErbB2 Interacting Protein (ERBB2IP) ELISA Kit Customized Service Offer
  1. "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor."Nat. Cell Biol. 2:407-414(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression."J. Biol. Chem. 276:32427-32436(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF."J. Biol. Chem. 277:12906-12914(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling."J. Biol. Chem. 280:40301-40309(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Novel mode of ligand recognition by the Erbin PDZ domain."J. Biol. Chem. 278:1399-1402(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain."J. Biol. Chem. 278:7645-7654(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Comparative structural analysis of the erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity."J. Biol. Chem. 281:22312-22320(2006) [PubMed] [Europe PMC] [Abstract]