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A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4)

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TSRC1; Thrombospondin Repeat Containing 1

A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4)
CCC L161
HGNC 19706
MGI 2389008
PubMed 21989719
RGD 1561012
UniProt Q6UY14
Wiki ADAMTSL4
ADAMTSL4 is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin Like Protein 4 (ADAMTSL4) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Placenta.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TSRC1, a widely expressed gene containing seven thrombospondin type I repeats."Gene 307:23-30(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90."FEBS Lett. 580:245-250(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis."Am. J. Hum. Genet. 84:274-278(2009) [PubMed] [Europe PMC] [Abstract]
  9. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A novel ADAMTSL4 mutation in autosomal recessive ectopia lentis et pupillae."Invest. Ophthalmol. Vis. Sci. 51:6369-6373(2010) [PubMed] [Europe PMC] [Abstract]
  11. "ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds Fibrillin-1 microfibrils and accelerates microfibril biogenesis."Invest. Ophthalmol. Vis. Sci. 53:461-469(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]