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Aflatoxin Aldehyde Reductase (AFAR)

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AKR7A2; AFAR1; AKR7; Aldo-Keto Reductase Family 7,Member A2; Aldoketoreductase 7; Succinic semialdehyde reductase; Aflatoxin B1 aldehyde reductase member 2

Aflatoxin Aldehyde Reductase (AFAR)
CCC L164
HGNC 389
MGI 107796
PubMed 12879023
RGD 620311
UniProt O43488
Wiki AKR7A2
Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones.Ireland et al. (1998) used a rat aflatoxin B1-aldehyde reductase (AFAR) cDNA and a human EST sequence to isolate human AFAR cDNAs from cerebellum and liver libraries. The full-length cDNA encodes a 330-amino acid polypeptide with 78% identity to rat AFAR, 22% identity to a Shaker-related voltage-gated potassium channel, and 16% identity to aldose reductase. Northern blot analysis revealed that AFAR is expressed in a wide range of human tissues.
AFAR can metabolize aflatoxin, but its specificity for some substrates differs from that of rat AFAR. They showed that AFAR is the principal human liver reductase for 2-carboxybenzaldehyde.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aflatoxin Aldehyde Reductase (AFAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aflatoxin Aldehyde Reductase (AFAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aflatoxin Aldehyde Reductase (AFAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aflatoxin Aldehyde Reductase (AFAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aflatoxin Aldehyde Reductase (AFAR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aflatoxin Aldehyde Reductase (AFAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aflatoxin Aldehyde Reductase (AFAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aflatoxin Aldehyde Reductase (AFAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aflatoxin Aldehyde Reductase (AFAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aflatoxin Aldehyde Reductase (AFAR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aflatoxin Aldehyde Reductase (AFAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aflatoxin Aldehyde Reductase (AFAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aflatoxin Aldehyde Reductase (AFAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aflatoxin Aldehyde Reductase (AFAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aflatoxin Aldehyde Reductase (AFAR) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase."Biochem. J. 332:21-34(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells."Cancer Res. 58:5014-5018(1998) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAR-2007) to UniProtKB
  6. "Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members."Biochem. J. 343:487-504(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins."Biochem. J. 366:847-861(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2."J. Biol. Chem. 282:25986-25992(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of the aflatoxin aldehyde reductase in complex with NADPH."Submitted (FEB-2009) to the PDB data bank
  12. "Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells."Cancer Lett. 272:160-166(2008) [PubMed] [Europe PMC] [Abstract]