≡

Absent, Small Or Homeotic Like Protein (ASH1L)

[Edit]

ASH1; ASH1L1; huASH1; KMT2H; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H; Histone-lysine N-methyltransferase ASH1L

Absent, Small Or Homeotic Like Protein (ASH1L)
CCC L165
HGNC 19088
MGI 2183158
PubMed 24012418
RGD 1306350
UniProt Q9NR48
Wiki ASH1L
ASH1L encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.The deduced 2,962-amino acid protein contains a SET domain, a PHD finger, and 4 AT hooks. It also has a bromodomain-like region that is not present in Drosophila Ash1. Northern blot analysis detected a 10.5-kb transcript expressed in all tissues examined, with highest levels in brain, kidney, and heart. Immunostaining of epithelial and breast cancer cell lines and primary foreskin fibroblasts detected expression of ASH1 in 2 distinct cellular compartments: in small speckles uniformly distributed throughout the nucleoplasm, and at cell-cell junctions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent, Small Or Homeotic Like Protein (ASH1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent, Small Or Homeotic Like Protein (ASH1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent, Small Or Homeotic Like Protein (ASH1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent, Small Or Homeotic Like Protein (ASH1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent, Small Or Homeotic Like Protein (ASH1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent, Small Or Homeotic Like Protein (ASH1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent, Small Or Homeotic Like Protein (ASH1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent, Small Or Homeotic Like Protein (ASH1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent, Small Or Homeotic Like Protein (ASH1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent, Small Or Homeotic Like Protein (ASH1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent, Small Or Homeotic Like Protein (ASH1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent, Small Or Homeotic Like Protein (ASH1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent, Small Or Homeotic Like Protein (ASH1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent, Small Or Homeotic Like Protein (ASH1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent, Small Or Homeotic Like Protein (ASH1L) ELISA Kit Customized Service Offer
  1. "huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions."Proc. Natl. Acad. Sci. U.S.A. 97:7284-7289(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism."J. Biol. Chem. 286:8369-8374(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]