ANAPC5 encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Anaphase Promoting Complex Subunit 5 (ANAPC5) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Anaphase Promoting Complex Subunit 5 (ANAPC5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Anaphase Promoting Complex Subunit 5 (ANAPC5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Anaphase Promoting Complex Subunit 5 (ANAPC5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Anaphase Promoting Complex Subunit 5 (ANAPC5) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Anaphase Promoting Complex Subunit 5 (ANAPC5) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Anaphase Promoting Complex Subunit 5 (ANAPC5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Anaphase Promoting Complex Subunit 5 (ANAPC5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Anaphase Promoting Complex Subunit 5 (ANAPC5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Anaphase Promoting Complex Subunit 5 (ANAPC5) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Anaphase Promoting Complex Subunit 5 (ANAPC5) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Anaphase Promoting Complex Subunit 5 (ANAPC5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Anaphase Promoting Complex Subunit 5 (ANAPC5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Anaphase Promoting Complex Subunit 5 (ANAPC5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Anaphase Promoting Complex Subunit 5 (ANAPC5) | ELISA Kit Customized Service Offer |
- "Identification of a cullin homology region in a subunit of the anaphase-promoting complex."Science 279:1219-1222(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Mitotic regulation of the human anaphase-promoting complex by phosphorylation."EMBO J. 22:6598-6609(2003) [PubMed] [Europe PMC] [Abstract]
- "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for the subunit assembly of the anaphase-promoting complex."Nature 470:227-232(2011) [PubMed] [Europe PMC] [Abstract]
- "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
- "Molecular architecture and mechanism of the anaphase-promoting complex."Nature 513:388-393(2014) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]