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Anaphase Promoting Complex Subunit 4 (ANAPC4)

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APC4; Cyclosome subunit 4

Anaphase Promoting Complex Subunit 4 (ANAPC4)
CCC L192
HGNC 19990
MGI 1098673
PubMed 20596676
RGD 1306572
UniProt Q9UJX5
Wiki ANAPC4
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.
The deduced 809-amino acid APC4 protein did not appear to have a yeast homolog. Yu et al. (1998) stated that the APC is highly conserved from yeast to humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 4 (ANAPC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 4 (ANAPC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 4 (ANAPC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 4 (ANAPC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 4 (ANAPC4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 4 (ANAPC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 4 (ANAPC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 4 (ANAPC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 4 (ANAPC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 4 (ANAPC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anaphase Promoting Complex Subunit 4 (ANAPC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anaphase Promoting Complex Subunit 4 (ANAPC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anaphase Promoting Complex Subunit 4 (ANAPC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anaphase Promoting Complex Subunit 4 (ANAPC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anaphase Promoting Complex Subunit 4 (ANAPC4) ELISA Kit Customized Service Offer
  1. "Identification of a cullin homology region in a subunit of the anaphase-promoting complex."Science 279:1219-1222(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Mitotic regulation of the human anaphase-promoting complex by phosphorylation."EMBO J. 22:6598-6609(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C."Mol. Cell 20:867-879(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular architecture and mechanism of the anaphase-promoting complex."Nature 513:388-393(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]